Abstract
THE Ly phenotype of T cells which cooperate with B cells in the production of antibody has been described as Ly 1+2− (refs 1 and 2). Helper T cells are distinct from cytotoxic T cells (Ly 1− Ly 2+)1,2 and suppressor T cells (Ly 1−2+)3,4. In tissue culture, helper activity does not depend on the presence of intact T cells but can be mediated by cell-free supernatants from stimulated T cells. Stimulation with antigen induces the release of antigen-specific helper factors5,6 as well as factors which support antibody response against unrelated antigens7. Factors similar or identical to the latter are produced by splenic T cells in response to alloantigens8–10 and concanavalin A11. It is tacitly assumed that the mechanism by which helper T cells collaborate with B cells in the production of antibody is to be attributed to the release of these mediators. We report here that with respect to their Ly phenotypes, T cells which release T-cell replacing factor (TRF)8 in response to alloantigen belong to the same subpopulation of T cells as helper cells.
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PICKEL, K., HÄMMERLING, U. & HOFFMANN, M. Ly phenotype of T-cells releasing T-cell replacing factor. Nature 264, 72 (1976). https://doi.org/10.1038/264072a0
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DOI: https://doi.org/10.1038/264072a0
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