Abstract
RNA polymerase is an allosteric enzyme whose activity and specificity are controlled by interaction with a nucleotide, tRNA and proteins. In E. coli the availability of these effectors should ensure that the quality of transcription is tightly coupled both to translation and to the metabolic state of the cell.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burgess, R. R., J. biol. Chem., 244, 6168–6176 (1969).
Kuntzel, H., and Schafer, K. P., Nature new Biol., 231, 265–269 (1975).
Gallant, J., and Lazzarini, R. A., in Protein Synthesis. A Series of Advances (edit. by McConkey, E. H.), (New York, Dekker, 1975).
Saucier, J. M., and Wang, J. C., Nature new Biol., 239, 167–170 (1972).
Travers, A., Baillie, D. L., and Pedersen, S., Nature new Biol., 243, 161–163 (1973).
Mangel, W. F., and Chamberlin, M., J. biol. Chem., 249, 3002–3006 (1974).
Nakanishi, S., Adhya, S., Gottesman, M., and Pastan, I., J. biol. Chem., 249, 4050–4056 (1974).
Richardson, J. P., Proc. natn. Acad. Sci. U.S.A., 55, 1616–1623 (1966).
Bahr, W., Standen, W., Scheit, K. H., and Jovin, T. M., in RNA polymerases (edit. by Chamberlin, M. J., and Losick, R.), (Cold Spring Harbor Laboratory, New York, in the press).
Primakoff, P., and Berg, P., Cold Spring Harb. Symp. quant. Biol., 35, 275–295 (1970).
Cashel, M., J. biol. Chem., 244, 3133–3141 (1969).
Cashel, M., and Gallant, J., Nature, 221, 838–841 (1969).
Reiness, G., Yang, H. L., Zubay, G., and Cashel, M., Proc. natn. Acad. Sci. U.S.A., 72, 2881–2885 (1975).
Block, R., in Control of Ribosome Synthesis (edit. by Maaloe, O., and Kjeldgaard, N. O.), 226 (Munksgaard, Copenhagen, 1976).
Travers, A., Kamen, R., and Cashel, B., Cold Spring Harb. Symp. quant. Biol., 35, 415–418 (1970).
van Ooyen, A. J. J., de Boer, H. A., Ab, G., and Gruber, M., Nature, 254, 530–531 (1975).
Travers, A., Molec. gen. Genet., 147, 225–232 (1976).
van Ooyen, A. J. J., Gruber, M., and Jorgensen, P., Cell, 8, 123–128 (1976).
Cashel, M., Cold Spring Harb. Symp. quant. biol., 35, 407–413 (1970).
Nomura, M., Okomoto, K., and Asano, K., J. molec. Biol., 4, 376–387 (1962).
Landy, A., and Spiegelman, S., Biochemistry, 7, 585–591 (1968).
Adesnik, M., and Levinthal, C., J. molec. Biol., 48, 187–208 (1970).
Walter, G., Seifert, W., and Zillig, W., Biochem. biophys. Res. Commun., 30, 240–247 (1968).
Goff, C. G., J. biol. Chem., 249, 6181–6190 (1974).
Stevens, A., Proc. natn. Acad. Sci. U.S.A., 69, 603–607 (1976).
Horvitz, H. R., Nature new Biol., 244, 137–140 (1973).
Ratner, D., J. molec. Biol., 89, 803–807 (1974).
Haseltine, W. A., Nature, 235, 329–333 (1972).
Baralle, F. E., and Travers, A., Molec. gen. Genet., 147, 291–298 (1976).
Horvitz, H. R., J. molec. Biol., 90, 739–750 (1974).
Travers, A., Nature, 244, 15–18 (1973).
Travers, A., FEBS Lett., (in the press).
Jacobson, A., and Gillespie, D., Cold Spring Harb. Symp. quant. Biol., 35, 85–93 (1970).
Johnsen, M., and Fiil, N. P., in Control of Ribosome Synthesis (edit. by O. Maaloe and N. O. Kkeldgaard), 221 (Munksgaard, Copenhagen, 1976).
Debenham, P., and Travers, A., Eur. J. Biochem. (in the press).
Cashel, M., Hamel, E., Shapshak, P., and Boquet, M., in Control of Ribosome Synthesis (edit. by Maaloe, O., Kjeldgaard, N. O.), 279 (Munksgaard, Copenhagen, 1976).
Pedersen, F. S., Lund, E., and Kjeldgaard, N. O., Nature new Biol., 243, 13–15 (1973).
Haseltine, W. A., and Block, R., Proc. natn. Acad. U.S.A., 70, 1564–1568 (1973).
Friesen, J. D., Fiil, N. P., and von Meyenburg, K., J. biol. Chem., 250, 304–309 (1975).
Hansen, M. T., Pato, M. L., Molin, S., Fiil, N. P., and von Meyenburg, K., J. Bact., 122, 585–591 (1975).
Chakrabarti, S. L., and Gorini, L., Proc. natn. Acad. Sci. U.S.A., 72, 2084–2087 (1975).
Muto, A., Kimura, A., and Osawa, S., Molec. gen. Genet., 139, 321–327 (1975).
Kimura, A., Muto, A., and Osawa, S., Molec. gen. Genet., 130, 203–214 (1974).
Pongs, O., and Ulbrich, N., Proc. natn. Acad. Sci. U.S.A., 73, 3064–3067 (1976).
Maaloe, O., Devl Biol. Supp., 3, 33–58 (1969).
Gausing, K., in Control of Ribosome Synthesis (edit. by Maaloe, O., and Kjeldgaard, N. O.), 292 (Munksgaard, Copenhagen, 1976).
Dennis, P. P., and Nomura, M., in Control of Ribosome Synthesis (edit. by Maaloe, O., and Kjeldgaard, N. O.), 304 (Munksgaard, Copenhagen, 1976).
Ratner, D., J. molec. Biol., 88, 373–383 (1974).
Fukuda, R., Iwakura, Y., and Ishihama, A., J. molec. Biol., 83, 353–367 (1974).
Losick, R., Sonenshein, A. L., Shorenstein, R. G., and Hussey, C., Cold Spring Harb. Symp. quant. Biol., 35, 443–450 (1970).
Biswas, B. B., Ganguly, A., and Das, D., Prog. Nucl. Acid Res. molec. Biol., 15, 145–184 (1975).
Klein, C., FEBS Lett., 38, 149–152 (1974).
McNaughton, D. R., Klassen, G. R., and Lejohn, H. B., Biochem. biophys. Res. Commun., 66, 468–474 (1975).
Lejohn, H. B., Cameron, L. E., McNaughton, D. R., and Klassen, G. R., Biochem. biophys. Res. Commun., 66, 460–467 (1975).
Finamore, F. J., and Warner, A. H., J. biol. Chem., 238, 344–348 (1963).
Warner, A. H., and Finamore, F. J., Biochim. biophys. Acta, 108, 525–530 (1965).
Ensinger, M. J., Martin, S. A., Paoletti, E., and Moss, B., Proc. natn. Acad. Sci. U.S.A., 71, 3465–3469 (1975).
Author information
Authors and Affiliations
Additional information
The erratum article can be found online at https://doi.org/10.1038/264196d0
Rights and permissions
About this article
Cite this article
Travers, A. RNA polymerase specificity and the control of growth. Nature 263, 641–646 (1976). https://doi.org/10.1038/263641a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/263641a0
This article is cited by
-
Transcriptional specificity after mycobacteriophage I3 infection
Journal of Biosciences (1987)
-
Selective inhibition of transcription of the E. coli tufB operon by guanosine-5′-diphosphate-3′-diphosphate
Molecular and General Genetics MGG (1983)
-
Biosynthesis of RNA polymerase in Escherichia coli
Molecular and General Genetics MGG (1982)
-
GTP pool expansion is necessary for the growth rate increase occurring in Bacillus subtilis after amino acids shift-up
Archives of Microbiology (1982)
-
Mapping of two transcription mutations (tlnI and tlnII) conferring thiolutin resistance, adjacent to dnaZ and rho in Escherichia coli
Molecular and General Genetics MGG (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.