Abstract
Rabbit aorta contracting substance-releasing factor (RCS-RF) is found in perfusates from guinea pig lungs during anaphylaxis. It has been identified as a small peptide which releases arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and thromboxanes and causing bronchoconstriction. Anti-inflammatory steroids block the release of arachidonate by RCS-RF. In this activity their relative potency is very similar to their relative anti-inflammatory potency, suggesting that the two actions may be related.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Piper, P. J., and Vane, J. R., Nature, 223, 29–35 (1969).
Svensson, J., Hamberg, M., and Samuelsson, B., Acta. physiol. scand., 94, 222–228 (1975).
Bunting, S., Moncada, S., and Vane, J. R., Br. J. Pharmac. 57, 462P–463P (1976).
Vane, J. R., Nature new Biol., 231, 232–235 (1971).
Brocklehurst, W. E., J. Physiol., Lond., 157, 416–435 (1960).
Ferreira, S. H., Bartelt, D. C., and Greene, L. J., Biochemistry, 9, 2583–2594 (1970).
Orange, R. P., Murphy, R. C., and Austin, K. F., J. Immun., 113, 316–322 (1974).
Sayers, G., and Travis, R. H., in The Pharmacological Basis of Therapeutics, fourth ed. (edit. by Goodman, L. S., and Gilman, A.), 1604–1642 (Macmillan, New York, 1970).
Hamberg, M., and Samuelson, B., Biochem. biophys. Res. Commun., 61, 942–949 (1974).
Hamberg, M., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 71, 3400–3404 (1974).
Flower, R. J., and Blackwell, G. J., Biochem. Pharmac., 25, 285–291 (1976).
Austen, K. F., and Orange, R. P., Am. Rev. respir. Dis., 112, 423–436 (1975).
Flower, R. J., Pharmac. Rev., 26, 33–67 (1974).
Lewis, G. P., and Piper, P. J., Nature, 254, 308–311 (1975).
Gryglewski, R. J., Panczenko, B., Korbut, R., Grodzinska, L., and Ocetkiewicz, A., Prostaglandins, 10, 343–355 (1975).
Tashjian, A. H., Voelkel, E. F., McDonough, J., and Levine, L., Nature, 258, 739–741 (1976).
Kantrowitz, F., Robinson, D. W., McGuire, M. B., and Levine, L., Nature, 258, 737–739 (1976).
Vargaftig, B. B., and Dao Hai, N., J. Pharm. Pharmac., 24, 159–161 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nijkamp, F., Flower, R., Moncada, S. et al. Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids. Nature 263, 479–482 (1976). https://doi.org/10.1038/263479a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/263479a0
This article is cited by
-
Annexin‐A1: a pivotal regulator of the innate and adaptive immune systems
British Journal of Pharmacology (2008)
-
A novel approach to the discovery of non-systemic anti-inflammatory steroids; Antedrug
Archives of Pharmacal Research (1999)
-
Background and discovery of lipocortins
Agents and Actions (1986)
-
Pharmacological studies on nonimmunologic contact urticaria in guinea pigs
Archives of Dermatological Research (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.