Abstract
PHOSPHONOACETIC acid (PAA) is an inhibitor of herpes simplex virus and of several other herpes viruses. It acts as a specific inhibitor of two viral DNA polymerases, those of herpes simplex and of Marek's disease (a herpes-induced leukaemia in chickens)1,2. We have used PAA as a probe to investigate the possible existence of a virus-directed DNA polymerase and its role in replication of viral genomes during the transformation and proliferation of normal human peripheral lymphocytes induced by Epstein–Barr virus (EBV), -which is a herpes virus closely associated with the development of several neoplasms in man.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mao, J. C-H., and Robishaw, E. E., Biochemistry, 14, 5475–5479 (1975).
Leinbach, S. S., Reno, J. M., Lee, L. F., Isbell, A. F., and Boezi, J. A., Biochemistry, 15, 426–429 (1976).
Gergely, L., Klein, G., and Ernberg, I., Int. J. Cancer, 7, 293–302 (1971).
Nyormoi, O., Thorley-Lawson, D. A., Elkington, J., and Strominger, J. L., Proc. natn. Acad. Sci. U.S.A., 73, 1745–1748 (1976).
Summers, W. C., and Klein, G., J. Virol, 18, 151–155 (1976).
Yajima, Y., Tanaka, A., Tanaka, A., and Nonoyama, M., Virology, 71, 352–354.
Gerber, P., and Hoyer, B. H., Nature, 231, 46–47 (1971).
Robinson, J., and Miller, G., J. Virol., 15, 1065–1072 (1975).
Moss, D. J., and Pope, J. H., Int. J. Cancer, 15, 503–511 (1975).
Pagano, J. S., J. infect. Dis., 132, 204–223 (1975).
Boyum, A., Scand. J. clin. Lab. Invest., 21, 31–89 (1968).
Chess, L., MacDermott, R. P., Sondel, P. M., and Schlossman, S. F., Prog Immun. II, 3 (edit. by Brent, L., and Holborrow, J.), (North-Holland, Amsterdam, 1974).
Klein, G., Giovanella, B., Westman, A., Stehlin, J. S., and Mumford, D., Intervirology (in the press).
Reedman, B. M., and Klein, G., Int. J. Cancer, 11, 499–520 (1973).
Klein, G., Dombos, L., and Gothoskar, B., Int. J. Cancer, 10, 44–57 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
THORLEY-LAWSON, D., STROMINGER, J. Transformation of human lymphocytes by Epstein-Barr virus is inhibited by phosphonoacetic acid. Nature 263, 332–334 (1976). https://doi.org/10.1038/263332a0
Issue Date:
DOI: https://doi.org/10.1038/263332a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
