Abstract
WE have recently been studying cultured cells derived from the androgen-responsive mouse mammary tumour, Shionogi 115 (S115)1,2. Here we show, from time-lapse cinemicrographic analysis of these cells, that regulation of proliferation rates by both cell population density and physiological concentrations of testosterone is achieved by changes in ‘transition probability’.
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ROBINSON, J., SMITH, J., TOTTY, N. et al. Transition probability and the hormonal and density-dependent regulation of cell proliferation. Nature 262, 298–300 (1976). https://doi.org/10.1038/262298a0
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DOI: https://doi.org/10.1038/262298a0
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