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Repeated sequence specific to human males

Abstract

Restriction enzyme analysis and nucleic acid hybridisation show that there is a repeated sequence in human male DNA which is not present in human female DNA. This sequence is shown to constitute about 50% of the DNA in the Y chromosome and is a simple tandemly repeated DNA.

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References

  1. Britten, R. J., and Davidson, E. H., Science, 165, 349–357 (1969).

    Article  ADS  CAS  Google Scholar 

  2. Laird, C. D., et al., Cold Spring Harb. Symp. quant Biol., 38, 311–327 (1973).

    Article  Google Scholar 

  3. Sutton, W. D., Nature new Biol., 237, 70–71 (1972).

    Article  CAS  Google Scholar 

  4. Pardue, M. L., and Gall, J. G., Science, 168, 1356–1368 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Jones, K. W., Nature, 225, 912–915 (1970).

    Article  ADS  CAS  Google Scholar 

  6. Pardue, M. L., and Birnstiel, M. L., Symp. Medica Hoescht, 6, 75–85 (1972).

    Google Scholar 

  7. Ruddle, F., Nature, 242, 165–169 (1973).

    Article  ADS  CAS  Google Scholar 

  8. Yoshimuri, R. N., thesis, Univ. California (1971).

  9. Middleton, J. H., Edgell, M. H., and Hutchison, C. A., J. Virol., 10, 42–50 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Philippsen, P., Streeck, R. F., and Zachau, H. G., Eur. J. Biochem., 45, 479–488 (1974).

    Article  CAS  Google Scholar 

  11. Danna, K. J., Sack, G. H., and Nathans, D., J. molec. Biol., 78, 363–376 (1973).

    Article  CAS  Google Scholar 

  12. Cooke, H. J., J. molec. Biol., 94, 87–99 (1975).

    Article  CAS  Google Scholar 

  13. Thomas, M., and Davis, R. W., J. molec. Biol., 91, 315–328 (1975).

    Article  CAS  Google Scholar 

  14. Southern, E. M., J. molec. Biol., 94, 51–69 (1975).

    Article  CAS  Google Scholar 

  15. Kimura, M., Cold Spring Harb. Symp. quant. Biol., 38, 515–524 (1973).

    Article  Google Scholar 

  16. Corneo, G., Ginelli, E., Biochim. biophys. Acta, 247, 528–534 (1971).

    Article  CAS  Google Scholar 

  17. Murray, K., Murray, N. E., and Brammer, W. J., Proc. 10th FEBS Meeting, 193–207 (1975).

  18. Walker, P. M. B., Prog. Biophys. Acta, 247, 528–534 (1971).

    Google Scholar 

  19. Southern, E. M., Symp. Medica Hoescht, 6, 19–27 (1972).

    Google Scholar 

  20. Southern, E. M., J. molec. Biol., 98, 503–518 (1975).

    Article  CAS  Google Scholar 

  21. Biro, P. A., Carr-Brown, A., Southern, E. M., and Walker, P. M. B., J. molec. Biol., 94, 71–86 (1975).

    Article  CAS  Google Scholar 

  22. Southern, E. M., Nature, 227, 794–798 (1970).

    Article  ADS  CAS  Google Scholar 

  23. Gall, J. G., and Atherton, D. D., J. molec. Biol. 85, 633–664 (1974).

    Article  CAS  Google Scholar 

  24. Mendelsohn, M. L., et al., Ann. N. Y. Acad. Sci, 157, 376–383 (1969).

    Article  ADS  Google Scholar 

  25. Arrighi, F. E., and Hsu, T. C., Cytogenetics, 10, 81–86 (1971).

    Article  CAS  Google Scholar 

  26. Ohno, S., Nature, 234, 134–137 (1971).

    Article  ADS  CAS  Google Scholar 

  27. Wachtel, S. S., Ohno, S., Koo, G. C., and Boyse, E. A., Nature, 257, 235–236 (1975).

    Article  ADS  CAS  Google Scholar 

  28. Bennett, D., Boyse, E. A., Lyon, M. F., Mathieson, B. J., Scheid, M., and Yanagisawa, K., Nature, 257, 236–238 (1975).

    Article  ADS  CAS  Google Scholar 

  29. Jacobs, P. A., and Ross, A., Nature, 210, 352–354 (1966).

    Article  ADS  CAS  Google Scholar 

  30. Yasmineh, W. G., and Yunis, J. J., Biochem. biophys. Res. Commun., 35, 779–781 (1969).

    Article  CAS  Google Scholar 

  31. Gosden, J. R., Mitchell, A. R., Buckland, R. A., Clayton, R. P., and Evans, H. J., Expl Cell Res., 92, 148–158 (1975).

    Article  CAS  Google Scholar 

  32. Ohno, S., Sex Chromosomes and Sex Linked Genes (Springer-Verlag, Berlin, 1967).

    Book  Google Scholar 

  33. Hulten, M., Lindsten, J., Pen-Ming, L. M., and Faraccaro, M., Ann hum. Genet., 30, 119–123 (1966).

    Article  CAS  Google Scholar 

  34. Pearson, P. L., and Bobrow, M., Nature, 226, 959–961 (1970).

    Article  ADS  CAS  Google Scholar 

  35. Bobrow, M., Pearson, P. L., and Collacott, H. E. A. C., Nature, 232, 555–557 (1971).

    Article  ADS  Google Scholar 

  36. Solari, A. J., Int. Rev. Cytol., 38, 273–317 (1974).

    Article  ADS  CAS  Google Scholar 

  37. Smith, G., Cold Spring Harb. Symp. quant. Biol., 38, 507–523 (1973).

    Article  Google Scholar 

  38. Kunkel, L. M., Smith, K. D., and Boyer, S. H., Science, 191, 1189–1190 (1976).

    Article  ADS  CAS  Google Scholar 

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Cooke, H. Repeated sequence specific to human males. Nature 262, 182–186 (1976). https://doi.org/10.1038/262182a0

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