Abstract
CONSIDERABLE evidence derived from the study of animal cells cultured in vitro implicates the cell surface in the regulation of cell division and in the expression of the phenotypic state of the cell. Cell surface is a broad term used to indicate the lipid bilayer of the cytoplasmic membrane containing intrinsic (stably integrated) and peripheral (easily removable) protein constituents plus carbohydrate complexes1–3. There are indications that some of the intrinsic constituents are of fundamental importance in certain physiological processes such as ion transport and transport of metabolic precursors4–8. On the other hand, it is not known whether components that are more loosely bound to the cell surface play any specific role in cell physiology because no cellular function has so far been examined in relation to such components. We report here that determination of cell shape is affected by a cell surface protein component easily detachable from the cell exterior.
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MALLUCCI, L., WELLS, V. Determination of cell shape by a cell surface protein component. Nature 262, 138–141 (1976). https://doi.org/10.1038/262138a0
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DOI: https://doi.org/10.1038/262138a0
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