Abstract
Two events are essential for successful lysogenisation by bacteriophage λ : establishment of repression and integration of the viral genome into the bacterial chromosome. Integration is catalysed by the phage Int function1. The int gene is situated at the distal end of the early leftward N operon, whose transcription is initiated at the PL promoter (Fig. 1). But in addition to PL-promoted transcription, the int gene is specifically activated by the action of the cII and cIII gene products, and we have proposed that the cII and cIII proteins stimulate fast synthesis of Int by acting at the PL promoter (my unpublished work with M. Katzir, M. Belfort and A. Oppenheim). In this respect the int gene behaves similarly to the cI repressor gene, whose fast expression is activated by the gene products of cII and cIII2,3.
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OPPENHEIM, A. Internal inversion used to study regulation of the int gene in bacteriophage λ. Nature 261, 615–616 (1976). https://doi.org/10.1038/261615a0
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DOI: https://doi.org/10.1038/261615a0
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