Abstract
CELLULAR secretions from either exocrine or endocrine glands are regulated in most cases by hormonal or neurohormonal agents. These chemical messengers interact with cellular receptors to stimulate a particular secretory response. In general, it would seem that changes in the transmembrane electrical potential of the secretory unit is in some way intimately involved in this stimulus–secretion coupling1. Here we provide evidence of cellular secretion resulting from spontaneous electrical activity (most probably depolarisations) after removal of a previously inhibitory stimulus.
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References
Matthews, E. K., in Secretory Mechanisms of Exocrine Glands (edit. by Thorn, N. A., and Paterson, O. H.), 185–198 (Academic Press, New York, 1974).
Hadley, M. E., and Bagnara, J. T., Am. Zool., 15, 81–104 (1975).
Bagnara, J. T., and Hadley, M. E., Chromatophores and Color Change: the Comparative Physiology of Animal Pigmentation (Prentice-Hall, Englewood Cliffs, New Jersey, 1973).
Etkin, W., Gen. comp. Endocr. Suppl., 1, 148–159 (1962).
Parsons, J. A., J. Physiol, Lond., 210, 973–987 (1970).
Hadley, M. E., Bower, Sr. A., and Hruby, V. J., Yale J. Biol. Med., 46, 602–616 (1973).
Dierst-Davies, K., Ralph, C. L., and Pechersky, J. L., Gen. comp. Endocr., 6, 409–419 (1966).
Dawson, D. C., and Ralph, C. L., Neuroendocrinology, 15, 267–280 (1974).
Enemar, A., and Falck, B., Gen. comp. Endocr., 5, 577–583 (1965).
Hopkins, C. R., Gen. comp. Endocr., 16, 112–120 (1971).
Nakai, Y., and Gorbman, A., Gen. comp. Endocr., 13, 108–116 (1969).
Iturriza, F. C., and Kasal-Iturriza, M., Gen. comp. Endocr. Suppl., 3, 108–113 (1972).
Bower, A., Hadley, M. E., and Hruby, V. J., Science, 184, 70–72 (1974).
Oshima, K., and Gorbman, A., Gen. comp. Endocr., 13, 98–107 (1969).
Huntington, T., and Hadley, M. E., Endocrinology, 96, 472–479 (1974).
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DUFF DAVIS, M., HADLEY, M. Spontaneous electrical potentials and pituitary hormone (MSH) secretion. Nature 261, 422–423 (1976). https://doi.org/10.1038/261422a0
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DOI: https://doi.org/10.1038/261422a0
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