Abstract
RECENTLY a direct correlation has been reported between spontaneous motor activity, tyrosine hydroxylase activity and the responsiveness of the noradrenaline sensitive cyclic AMP-generating system in rat brain1,2. These observations may indicate that the turnover and/or level of noradrenaline in the brain is important in determining the sensitivity of the cyclic AMP-generating system to noradrenaline. Indeed, it has been shown that depletion of brain noradrenaline by the intraventricular injection of 6-hydroxydop-amine results in supersensitivity of the system to noradrenaline3,4. Furthermore treatment with reserpine, a drug known to cause depressive reactions in man, has been reported to increase the sensitivity of the adenylate cyclase of rat brain to noradrenaline5 and several antidepressant drugs have been shown to have the opposite effect in limbic forebrain6. By contrast, we now present evidence that the chronic treatment of rats with both an antidepressant, imipramine, and a depressant, chlorpromazine, reduces the sensitivity of the cyclic AMP-generating system to noradrenaline.
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SCHULTZ, J. Psychoactive drug effects on a system which generates cyclic AMP in brain. Nature 261, 417–418 (1976). https://doi.org/10.1038/261417a0
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DOI: https://doi.org/10.1038/261417a0
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