Abstract
ACETYLCHOLINE receptors in vertebrates can be classified in two categories—nicotinic and muscarinic—on the basis of differential sensitivity to agonist and antagonist compounds1,2. This pharmacological distinction, although useful both in therapeutics and in experimental physiology, has no known biological significance. I wish to show here that there are marked kinetic differences between nicotinic and muscarinic receptors, and to suggest that these differences have a clear physiological meaning.
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References
Dale, H. H., J. Pharmac. exp. Ther., 6, 147–190 (1914).
Koelle, G. B., in The Pharmacological Basis of Therapeutics (edit. by Goodman, L. S., and Gilman, A.), Ch. 21, 402–441 (Macmillan, New York, 1970).
Brown, G. L., and Eccles, J. C., J. Physiol., Lond., 82, 211–241 (1934).
del Castillo, J., and Katz, B., Nature, 175, 1035 (1955). del Castillo, J., and Katz, B., in Microphysiologie Comparée des Eléments Excitables, Coll. int. Centre National de la Recherche Scientifique, 67, 271–278 (1957).
Bennett, M. R., J. Physiol., Lond., 185, 132–147 (1966).
Ohashi, H., Jap. J. Pharmac., 21, 585–596 (1971).
Creed, K. E., and McDonald, I. R., J. Physiol., Lond., 247, 521–535 (1975).
Hubbard, J. I., and Schmidt, R. F., J. Physiol., Lond., 166, 145–167 (1963).
Blackman, J. G., and Purves, R. D., J. Physiol., Lond., 203, 173–198 (1969).
Tosaka, T., Chichibu, S., and Libet, B., J. Neurophysiol., 31, 396–409 (1968).
Burnstock, G., in Smooth Muscle (edit. by Bülbring, E., Brading, A. W., and Tomita, T.), 1–69 (Edward Arnold, London, 1970).
Anderson-Cedergren, E., J. Ultrastruct. Res., 3, Suppl. 1, 1–191 (1959).
Purves, R. D., Br. J. Pharmac., 52, 77–86 (1974).
Bolton, T. B., Br. J. Pharmac., 55, 304P (1975).
Nishiyama, A., and Petersen, O. H., J. Physiol., Lond., 244, 431–465 (1975).
Valentinuzzi, M. E., Hoff, H. E., and Geddes, L. A., Circulation Res., 33, 532–538 (1973).
Dennis, M. J., Harris, A. J., and Kuffler, S. W., Proc. R. Soc., B 177, 509–539 (1971).
Barr, L., Dewey, M. M., and Berger, W., J. gen. Physiol., 48, 797–823 (1965).
Gaskell, W. H., Phil. Trans. R. Soc., 173, 993–1033 (1882).
Toda, N., and Shimamoto, K., J. Pharmac. exp. Ther., 159, 298–305 (1968).
Kuriyama, H., J. Physiol., Lond., 169, 213–228 (1963).
George, W. J., Polson, J. B., O'Toole, J. B., and Goldberg, N. D., Proc. natn. Acad. Sci. U.S.A., 66, 398–403 (1970).
Bar, H. P., Adv. Cyclic Nucleotide Res., 4, 195–237 (1974).
Kebabian, J. W., Steiner, A. L., and Greengard, P., J. Pharmac. exp. Ther., 193, 474–488 (1975).
Sutherland, E. W., and Robison, G. A., Pharmac. Rev., 18, 145–161 (1966).
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PURVES, R. Function of muscarinic and nicotinic acetylcholine receptors. Nature 261, 149–151 (1976). https://doi.org/10.1038/261149a0
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DOI: https://doi.org/10.1038/261149a0
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