Abstract
ELECTRICAL activity in certain molluscan neurones is subject to long lasting synaptic and hormonal modulation1–5. Evidence from several systems suggests that cyclic nucleotides mediate alterations in membrane properties in nerve and muscle cells6–8. We report here that, in certain neurones from the marine snail Aplysia californica and the land snail Helix pomatia, an increase in the intracellular concentration of cyclic nucleotides is accompanied by long lasting changes in electrical activity, and that physiological agents known to modify the electrical rhythms of these nerve cells, increase adenosine 3′, 5′-cyclic monophosphate (cyclic AMP) in Helix and Aplysia nervous tissue.
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TREISTMAN, S., LEVITAN, I. Alteration of electrical activity in molluscan neurones by cyclic nucleotides and peptide factors. Nature 261, 62–64 (1976). https://doi.org/10.1038/261062a0
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DOI: https://doi.org/10.1038/261062a0
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