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Single-stranded regions in regenerating rat liver DNA

Abstract

SEVERAL groups have identified single-stranded regions in actively replicating eukaryote DNA1–5. We have used isopycnic caesium sulphate gradients containing silver ion, and a single-strand-specific endonuclease to determine the single strandedness of DNA from actively regenerating rat liver, and from ‘control’ liver of partially hepatectomised rats that had been allowed to regenerate their normal liver mass. More single-stranded DNA was observed in regenerating liver than in control livers.

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HOFFMAN, L., COLLINS, J. Single-stranded regions in regenerating rat liver DNA. Nature 260, 642–643 (1976). https://doi.org/10.1038/260642a0

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