Abstract
THERE is evidence which suggests that the release of gonadotropin-releasing hormone (GRH) is modulated by dopaminergic neurones1–3. Dopamine receptors seem to be hyper-responsive in Huntington's chorea4,5, and consequently the synthesis and secretion of GRH may be altered in this condition. For this reason we have compared the concentration of immunoreactive GRH in hypothalamic tissues taken postmortem from choreic and non-choreic (‘control’) subjects. The distribution of GRH in the human brain, and changes in concentration which occur with age have also been examined.
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References
Schneider, H. P. G., and McCann, S. M., in Aspects of Neuroendocrinology (edit. by Bargmann, W., and Scharrer, B.), 177–191 (Springer, Berlin, 1970).
Porter, J. C., Kamberi, I. A., Goldman, B. D., Mical, R. S., and Grazia, Y. R., J. Reprod. Fert., suppl., 10, 39–47 (1970).
Fuxe, K., Hökfelt, T., and Nilsson, O., Acta endocr., Copenh., 69, 625–639 (1972).
Klawans, H. L., Jr, Eur. Neurol., 4, 148–163 (1970).
Podolsky, S., and Leopold, N. A., J. clin. Endocr. Metab., 39, 36–39 (1974).
Bird, E. D., and Iversen, L. L., Brain, 97, 457–472 (1974).
Nett, T. M., Akbar, A. M., Niswender, G. D., Hedlund, M. T., and White, W. F., J. clin. Endocr. Metab., 36, 880–885 (1973).
Fink, G., and Jamieson, M. G., J. Endocr., 68, 71–87 (1976).
King, J. C., Williams, T. H., and Arimura, A. A., J. Anat., 120, 275–288 (1975).
Sawyer, C. H., Neuroendocrinology, 17, 97–124 (1975).
Jamieson, M. G., and Fink, G., J. Endocr., 68, 57–70 (1976).
Fink, G., Clin. Endocrinol., 5, suppl., 245–260 (1976).
Martin, J. B., Renaud, L. P., and Brazeau, P., Lancet, ii, 393–395 (1975).
Bird, E. D., in Biochemistry and Neurology (edit. by Bradford, H. F., and Marsden, C. D.), 83–92 (Academic, London, 1976).
Wide, L., Nillius, S. J., Gemzell, C., and Roos, P., Acta endocr., Copenh., suppl., 174, 1–58 (1973).
Ryan, R. J., and Faiman, C., in Gonadotropins (edit. by Rosemberg, E.), 333–337 (Geron-X, Los Altos, 1968).
Schalch, O. S., Parlow, A. F., Boon, R. C., and Reichlin, S., J. clin. Invest., 47, 665–687 (1968).
Rubens, R., Dhont, M., and Vermeulen, A., J. clin. Endocr. Metab., 39, 40–45 (1974).
Diepen, R., Handbuch der Mikroskopischen Anatomie des Menschen (Der Hypothalamus) iv/7, 86 (Springer, Berlin, 1962).
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BIRD, E., CHIAPPA, S. & FINK, G. Brain immunoreactive gonadotropin-releasing hormone in Huntington's chorea and in non-choreic subjects. Nature 260, 536–538 (1976). https://doi.org/10.1038/260536a0
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DOI: https://doi.org/10.1038/260536a0
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