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Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

Nature volume 260, pages 101–108 (1976)Cite this article

Abstract

The postsynaptic actions of some neurotransmitters may be mediated through cyclic nucleotides and cyclic nucleotide-dependent phosphorylation of specific membrane proteins in postsynaptic cells. In addition to providing a molecular basis for the actions of several neurotransmitters and of certain drugs affecting behaviour, the model suggests a mechanism by which neurotransmitter signals may be converted into electrophysiological responses in postsynaptic cells.

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  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510

    Paul Greengard

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Greengard, P. Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†. Nature 260, 101–108 (1976). https://doi.org/10.1038/260101a0

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