Abstract
THE specific receptors for several non-enveloped viruses are present on cells in only limited numbers (1 × 104–10 × 104), and can therefore be saturated with excess virus1–5. An excess of inactivated poliovirus type 1 inhibits the attachment of infectious poliovirus of all 3 serotypes, but not the attachment of other viruses, including B Coxsackie viruses6. Most of the B Coxsackie viruses probably share the same receptor7, but Coxsackie viruses B1 and B3 do not compete for the poliovirus receptor1. Adenovirus 2 and 5 also appear to share the same receptor, since their attachment to host cells is blocked by an excess of the adenovirus type 2 fibre protein, which seems to be the receptor-recognising portion of the virus particle2. A number of other adenoviruses may also belong to the same receptor family since soluble antigens block their attachment to erythrocytes8. We here report results which permit the construction of a ‘receptor map’ for a number of non-enveloped viruses.
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LONBERG-HOLM, K., CROWELL, R. & PHILIPSON, L. Unrelated animal viruses share receptors. Nature 259, 679–681 (1976). https://doi.org/10.1038/259679a0
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DOI: https://doi.org/10.1038/259679a0
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