Abstract
ONE way to advance current physiological and biochemical understanding of the mechanism of synaptic transmission at the molecular level is to alter synaptic function by means of single gene mutations. Among the various behavioural mutants of Drosophila melanogaster, those which express a mutant phenotype only in certain conditions and otherwise behave normally are of particular interest. If the mutant phenotype appears at the synapse, the mutant might enable a reversible modification of synaptic function by way of experimentally controlling the expression of the mutant phenotype. Such a mutant would provide a useful tool for the study of synaptic function.
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IKEDA, K., OZAWA, S. & HAGIWARA, S. Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster. Nature 259, 489–491 (1976). https://doi.org/10.1038/259489a0
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DOI: https://doi.org/10.1038/259489a0
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