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Increased cyclic nucleotide phosphodiesterase activity in leukaemic lymphocytes

Nature volume 259, pages 321–323 (1976)Cite this article

Abstract

THE intracellular concentration of cyclic AMP influences cellular proliferation and maturation in both normal and malignant tissue. For example, the concentration of cyclic AMP—changes during the cell cycle being lowest during mitosis1—is inversely related to the rate of cell growth2, and is elevated in contact-inhibited cell populations3,4. In studies of malignant tissue, the concentration of cyclic AMP is lower in cells transformed in vitro by oncogenic viruses than in untransformed cells3–5, and is lower in certain tumours grown in vivo than in the corresponding normal tissue6,7. Furthermore, in malignant cells, exogenous cyclic AMP or agents that increase the intracellular concentration of this cyclic nucleotide decrease the rate of growth8 and induce morphological and biochemical differentiation9,10.

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Authors and Affiliations

  1. Department of Pharmacology, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, Pennsylvania, 19129

    WILLIAM N. HAIT & BENJAMIN WEISS

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  1. WILLIAM N. HAIT
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  2. BENJAMIN WEISS
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HAIT, W., WEISS, B. Increased cyclic nucleotide phosphodiesterase activity in leukaemic lymphocytes. Nature 259, 321–323 (1976). https://doi.org/10.1038/259321a0

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