Abstract
THE relationship between the major histocompatibility complex (MHC) and immune response (Ir) genes has been demonstrated in the case of several antigens, including some transplantation antigens1. Among these, some tumour-associated transplantation antigens (TATA) are probably included1. To date, however, few results are available to document this prediction. In the mouse quantitative transplantations of chemically-induced neoplasms suggest that the H−2-linked Ir genes of different F1 hybrids can control their susceptibility to parent-specific tumours2. This control, however, is certainly complex (that is, involving more than one gene), possibly because this sort of tumour can have different types of TATA3.
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OTH, D., ROBERT, F., BEREBBI, M. et al. Decreased resistance in some heterozygotes in H−2-linked immune response to polyoma-induced tumour. Nature 259, 316–317 (1976). https://doi.org/10.1038/259316a0
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DOI: https://doi.org/10.1038/259316a0
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