Abstract
BOTH intact bacillus Calmette–Guerin(BCG)1–3 and the methanol extraction residue (MER) fraction4 of BCG have had extensive application in tumour immunotherapy. Treatment with MER nonspecifically stimulates both the cellular and humoral immune systems4,5, and has been successful in tumour immunotherapy in a number of animal models6,7. Experiments in our laboratories, using animals obtained from the Weizmann Institute, Rehovot, Israel, have shown that about 40% of strain 2 guinea pigs injected with MER or with the supernatant of sonically-disrupted BCG (BCG SS), 1–2 months before intradermal inoculation with 106 cells of the transplantable line 10 hepatocarcinoma8,9, are resistant to the growth of this tumour10. Similarly, injection of MER into developing tumour nodules 7d after tumour cell implantation results in complete tumour regression in approximately 40% of the animals tested (M.A.W., P.M. and D.W.W., unpublished).
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WAINBERG, M., MINDEN, P. & WEISS, D. Vertical transmission of tumour resistance in guinea pigs. Nature 259, 213–215 (1976). https://doi.org/10.1038/259213a0
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DOI: https://doi.org/10.1038/259213a0
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