Abstract
HIGH levels of alpha foetoprotein (AFP), albumin and IgG have been detected in the cerebrospinal fluid (CSF) of six human foetuses between 16.5 and 25 weeks old1. The levels of AFP were found to decline from 1,200 µg ml−1 in a foetus of 16.5 weeks to 52 and 60 µg ml−1 in the older ones tested. During this period of foetal life, the ratios between albumin and AFP in CSF were shown to increase. The levels of IgG ranged between 60 and 117 µg ml−1 and were higher than those detected in CSF from normal adult subjects (20–40 µg ml−1)2.
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References
Seller, M., and Adinolfi, M., Archs Dis. Childh., 50, 454–485 (1975).
Laterre, E. C., Ric. Clin. Lab., 3, 736–763 (1973).
Hochwald, G. M., and Thorbecke, G. J., Proc. Soc. exp. Biol., 109, 91–95 (1962).
Penny, R., and Osserman, E. F., Aust. J. exp. Biol. Med., 49, 111–120 (1971).
Peterson, P. A., Ervin, P. F., and Beggard, I., J. clin. Invest., 48, 1189–1198 (1969).
Osserman, E. F., and Lawlor, D. P., J. exp. Med., 124, 921–952 (1966).
Weir, D. M., Handbook of Experimental Immunology, second ed. (Blackwell, Oxford, 1973).
Nellhaus, G., Archs Neurol., 24, 441–448 (1971).
Harms, D., Eur. Neurol., 13, 54–64 (1975).
Thorley, J. D., Holmes, R. K., Kaplan, J. M., McCraken, G. H., and Sanford, J. P., Lancet, i, 651–653 (1975).
Brock, D. J. H., and Sutcliffe, R. G., Lancet, ii, 197–199 (1972).
Adinolfi, A., Adinolfi, M., and Lessof, M. H., J. med. Genet., 12, 138–151 (1975).
Sonoda, S., and Schlamowitz, M., Immunochemistry, 7, 885–898 (1970).
Adinolfi, A., Adinolfi, M., and Cohen, S., Biochim. biophys. Acta, 251, 197–207 (1971).
Carp, R. I., Davidson, A. L., and Merz, P. A., Res. vet. Sci., 12, 499 (1971).
Dawson, H., Physiology of the Cerebrospinal Fluid (Churchill, London, 1967).
Dobbing, J., and Smart, J. L., Br. med. Bull., 30, 164–168 (1974).
Balazs, R., Br. med. Bull., 30, 126–134 (1974).
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ADINOLFI, M., BECK, S., HADDAD, S. et al. Permeability of the blood–cerebrospinal fluid barrier to plasma proteins during foetal and perinatal life. Nature 259, 140–141 (1976). https://doi.org/10.1038/259140a0
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DOI: https://doi.org/10.1038/259140a0
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