Abstract
SINCE the observation by Graves1 that swine vesicular disease virus (SVDV)2 is neutralised by antiserum to coxsackie B5 (CB5) virus, an enterovirus infecting man, and observations3 that the swine virus can also infect man, there has been speculation about the relationship between the two viruses and the possible role of CB5 virus in the aetiology of the swine disease4. Further work has shown that the two viruses can be differentiated by neutralisation tests and also that there has been considerable antigenic drift in the CB5 viruses5,6. RNA hybridisation experiments have corroborated these antigenic relationships; there is approximately 50% homology between the RNA of the UK isolate of SVDV and the RNA of the prototype (Faulkner) CB5 and there is a similar level of annealing between prototype CB5RNA and the RNA of two recent isolates of CB5 (8068 and 9954). These variations prompted an investigation into some of the other characteristics of SVDV and CB5.
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HARRIS, T., BROWN, F. Correlation of polypeptide composition with antigenic variation in the swine vesicular disease and coxsackie B5 viruses. Nature 258, 758–760 (1975). https://doi.org/10.1038/258758a0
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DOI: https://doi.org/10.1038/258758a0
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