Abstract
ADMINISTRATION of oestrogen or androgen to neonatal rats or mice can cause sterilisation of females1. Adult sterilised females generally exhibit masculinised behaviour and do not have normal cyclic gonadotropin patterns. Are prospective receptors for oestrogens and androgens present in neonatal rat or mouse brain tissues that are responsive to sex steroids? Direct demonstration of oestradiol receptor in brains of neonatal rats has been made difficult by the “neonatal binding protein” (NBP)2,3 that binds oestradiol with much higher capacity but lower affinity than does presumed receptor. If oestradiol receptor is present and functional, does NBP act in neonatal brain to prevent sterilisation by maternal oestrogens?3
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References
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Fox, T. Oestradiol receptor of neonatal mouse brain. Nature 258, 441–444 (1975). https://doi.org/10.1038/258441a0
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DOI: https://doi.org/10.1038/258441a0
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