Abstract
SEVERAL cellular mechanisms have been postulated to account for the phenomenon of transplantation tolerance in animals injected at birth with allogeneic or semiallogeneic cells. These include deletion of the clone of specific alloantigen sensitive cells1, continuous production of conventional blocking alloantibody2 or anti-receptor antibody3 and the action of suppressor cells4. Although these phenomena have been demonstrated in tolerant animals, it has never been shown that either alone or in combination they are actually capable of inducing true transplantation tolerance. In the course of experiments designed to prove formally that recirculating small lymphocytes are responsible for first-set rejection of skin grafts, we obtained results suggesting that rapidly recirculating cells from tolerant donors might be capable of actively transferring a state of transplantation tolerance (TT) to irradiated recipients5,6. These results, which suggested that the transfer of TT was due to humoral or cellular suppressor mechanisms, were not consistent with the clonal deletion theory of tolerance. The present experiments were designed to confirm that TT is not merely the absence of reactivity to a given set of allo-antigeneic determinants but an active suppression of reactivity to those determinants, and to determine whether T or B cells mediate this suppression.
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DORSCH, S., ROSER, B. T cells mediate transplantation tolerance. Nature 258, 233–235 (1975). https://doi.org/10.1038/258233a0
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DOI: https://doi.org/10.1038/258233a0
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