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Nuclease that preferentially inactivates DNA containing mismatched bases

Nature volume 258, pages 54–56 (1975)Cite this article

Abstract

Heteroduplex and homoduplex DNA molecules of bacteriophage SPP1 were treated with DNase I, an enzyme of Ustilago maydis implicated in genetic recombination. A transfection assay with Bacillus subtilis demonstrates that the heteroduplexes are preferentially inactivated.

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Author information

Author notes

  1. W. K. Holloman

    Present address: Department of Internal Medicine, School of Medicine, Yale University, 333 Cedar Street, New Haven, Connecticut, 06520

Authors and Affiliations

  1. Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 63-73, 1, Berlin, 33, Dahlem, West Germany

    A. Ahmad

  2. National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    R. Holliday

Authors
  1. A. Ahmad
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  2. W. K. Holloman
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  3. R. Holliday
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Ahmad, A., Holloman, W. & Holliday, R. Nuclease that preferentially inactivates DNA containing mismatched bases. Nature 258, 54–56 (1975). https://doi.org/10.1038/258054a0

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  • DOI: https://doi.org/10.1038/258054a0

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