Abstract
CYCLIC GMP has been postulated as one of the intracellular mediators triggering cell growth1. Exogenously added cylic GMP or its derivatives are liable to induce a substantial increase in DNA synthesis2–4 and to promote growth2,5. Cultured, non-transformed fibroblasts6 and lymphocytes1 exist in one of two reversible growth states, a state of rapid proliferation and a state of relative quiescence and increased levels of cylic GMP are correlated with the transition from the resting to the growth state1,3. In these systems, a variety of mitogenic agents have been shown to initiate proliferation of quiescent cells and this effect seems to be accomplished by interaction with the cell surface1. Therefore, if an increase in cylic GMP levels were to act as the intracellular signal triggering cell proliferation, its formation and/or degradation should be linked to events occurring in the plasma membrane. Indeed, a membrane-bound guany-late cyclase (GTP pyrophosphatelyase, cyclising, EC 4.6.1.2.) of cultured fibroblasts has been found to be activated by a fibroblast growth factor7.
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GORIDIS, C., REUTTER, W. Plasma membrane-associated increase in guanylate cyclase activity in regenerating rat liver. Nature 257, 698–700 (1975). https://doi.org/10.1038/257698a0
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DOI: https://doi.org/10.1038/257698a0
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