Abstract
IN the slowly adapting stretch receptor neurone of lobster, application of tetrodotoxin (TTX) causes a simultaneous hyperpolarisation and decrease in input resistance1. These effects have been attributed to a possible increase in potassium conductance. They could, however, be explained by elimination of a subthreshold steady-state sodium conductance which, in this case, might underlie the cell's repetitive mode of firing2. To examine this possibility, we made a voltage clamp study of the subthreshold steady-state membrane currents of the slowly adapting stretch receptor neurone of lobster. The results indicate the existence of a subthreshold steady-state Na current which to a large extent seems to be balanced by a leak type current.
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References
Albuquerque, E. X., and Grampp, W., J. Physiol., Lond., 195, 141 (1968).
Noble, D., Physiol. Rev., 46, 1 (1966).
Sjölin, L., and Grampp, W., Nature, 257, 696–697 (1975).
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Grampp, W., Acta physiol. scand., 66, Suppl. 262 (1966).
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GRAMPP, W., SJÖLIN, L. Subthreshold membrane currents in slowly adapting stretch receptor neurone of lobster. Nature 257, 697–698 (1975). https://doi.org/10.1038/257697a0
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DOI: https://doi.org/10.1038/257697a0
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