Abstract
MACROPHAGE proliferation occurs in vivo as a component of the inflammatory response1 and particularly intense proliferation is characteristic of the delayed hypersensitivity reaction to infection with facultative intracellular pathogens2–4. The thymus-derived (T) lymphocyte is considered responsible for the expansion of the reticuloendothelial system in this type of infection5. Although the mechanisms by which lymphocytes induce macrophage proliferation and activation remain unclear, a number of lymphocyte-produced soluble mediators which influence the functions of macrophages have been described, including a biochemically distinct migration inhibitory factor (MIF) and chemotactic factor (MCF)6. The speculation that a lymphocyte-produced mitogenic factor may be responsible for the induction and maintenance of proliferation of macrophages prompted the present experiments.
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HADDEN, J., SADLIK, J. & HADDEN, E. Macrophage proliferation induced in vitro by a lymphocyte factor. Nature 257, 483–485 (1975). https://doi.org/10.1038/257483a0
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DOI: https://doi.org/10.1038/257483a0
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