Abstract
THE adrenal glucocorticoids have been shown to be involved in the regulation of cyclic AMP activated metabolic processes such as lipolysis1, glycogenolysis2 and gluconeogenesis3. The role of the glucocorticoids in the regulation of these processes has been termed “permissive”4 since it enables the maintenance of the normal responsiveness of cells to hormones which act through cyclic AMP. Glucagon is known to activate the gluconeogenic pathway of mammalian liver at several sites5 including amino acid transport6. We have studied the hormonal regulation of amino acid transport in rat liver parenchymal cells maintained in culture and report here that the synthetic glucocorticoid, dexamethasone, has a “permissive” effect on the glucagon induction of amino acid transport in hepatocytes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fain, J. N., Kovacev, V. P., and Scow, R. O., J. biol. Chem., 240, 3522–3529 (1965).
Schaeffer, L. D., Chenoweth, M., and Dunn, A., Biochim. Biophys. Acta, 192, 304–309 (1969).
Exton, J. H., et al., J. biol. Chem., 247, 3579–3588 (1972).
Ingle, D. J., J. Endocr., 8, xxiii (1952).
Exton, J. H., Metabolism, 21, 945–990 (1972).
Mallette, L. E., Exton, J. H., and Park, C. R., J. biol. Chem., 244, 5724–5728 (1969).
Bonney, R. J., Becker, J. E., Walker, P. R., and Potter, V. R., In Vitro, 9, 399–413 (1974).
Pariza, M. W., Becker, J. E., Yager, J. D. Jr, Bonney, R. J., and Potter, V. R., in Differentiation and Control of Malignancy of Tumor Cells (edit. by Nakahara, W., Ono, T., Sugimura, T., and Sugano, H.), 257–284 (University Park Press, Baltimore, 1975).
Pariza, M. W., et al., in Expression and Carcinogenesis in Cultured Liver (edit. by Gerschenson, L. E., and Brad Thompson, E. B.) (Academic, New York, in the press).
Kletzien, R. F., and Perdue, J. F., J. biol. Chem., 249, 3366–3374 (1974).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Mallette, L. E., Exton, J. H., and Park, C. R., J. biol. Chem., 244, 5713–5723 (1969).
Felig, P., Pozefsky, T., Marliss, E., and Cahill, G. F. Jr, Science, 167, 1003–1004 (1970).
Bondy, P. K., Ingle, D. J., and Meeks, R. C., Endocrinology, 55, 354–360 (1954).
Smith, O. K., and Long, C. N. H., Endocrinology, 80, 561–566 (1967).
Exton, J. H., et al., Rec. Prog. Hormone Res., 26, 411–443 (1970).
Braun, T., and Hechter, O., Proc. natn. Acad. Sci. U.S.A., 66, 995–1001 (1970).
Noall, M. W., Riggs, T. R., Walker, L. M., and Christensen, H. N., Science, 126, 1002–1005 (1957).
Chambers, J. W., Georg, R. H., and Bass, A. D., Molec. Pharmacol., 1, 66–76 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KLETZIEN, R., PARIZA, M., BECKER, J. et al. A “permissive” effect of dexamethasone on the glucagon induction of amino acid transport in cultured hepatocytes. Nature 256, 46–47 (1975). https://doi.org/10.1038/256046a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/256046a0
This article is cited by
-
Precocious induction of arginase in primary cultures of fetal rat hepatocytes
In Vitro (1984)
-
Amino acid transport in isolated rat hepatocytes
The Journal of Membrane Biology (1982)
-
Growth and differentiation of human keratinocytes without a feeder layer or conditioned medium
In Vitro (1980)
-
The effects of dexamethasone on metabolic activity of hepatocytes in primary monolayer culture
In Vitro (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.