Abstract
DURING the past three years calcium ionophores have been increasingly used to study calcium-dependent mechanisms, for example, excitation–contraction coupling1 and stimulus–secretion coupling2–5. They seem to act by increasing the cytoplasmic ionised calcium concentration, but the mechanism of action does not seem to be identical in the different tissues studied. The calcium ionophore A23187 transports calcium from the extracellular space and intracellular sources towards the cytosol2,3 whereas another ionophore X537A (Lasalocid) seems to release calcium from intracellular binding sites only1,5. In addition, X537A does not seem to affect all the tissues studied so far—possibly because it does not readily penetrate cell membranes.
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NORDMANN, J., DYBALL, R. New calcium-mobilising agent. Nature 255, 414–415 (1975). https://doi.org/10.1038/255414a0
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DOI: https://doi.org/10.1038/255414a0
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