Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Initiator constitutive mutation with an ‘up-promoter’ effect in Aspergillus nidulans

Nature volume 254, pages 31–34 (1975)Cite this article

Abstract

A mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote Aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. In addition, it increases the maximal induced level of transport 2.5-fold. This is the first demonstration of an initiator or promoter mutation in an eukaryote.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Arst, H. N., Jr, and MacDonald, D. W., Nature, 254, 26–31 (1975).

    Article  ADS  CAS  Google Scholar 

  2. Scazzocchio, C., J. Less Common Metals, 36, 461–464 (1974).

    Google Scholar 

  3. Scazzocchio, C., Holl, F. B., and Foguelman, A. I., Eur. J. Biochem., 36, 428–445 (1973).

    Article  CAS  Google Scholar 

  4. Scazzocchio, C., Eur, J. Biochem., 36, 439–445 (1973).

    Article  Google Scholar 

  5. Arst, H. N., Jr, and Cove, D. J., Molcc. gen. Genet., 126, 111–141 (1973).

    Article  CAS  Google Scholar 

  6. Hopkins, J. D., J. molec. Biol., 87, 715–724 (1974).

    Article  CAS  Google Scholar 

  7. Lee, N., Wilcox, G., Gielow, W., Arnold, J., Cleary, P., and Englesberg, E., Proc. natn. Acad. Sci. U.S.A., 71, 634–638 (1974).

    Article  ADS  CAS  Google Scholar 

  8. Hua, S.-S., and Markovitz, A., Proc. natn. Acad. Sci. U.S.A., 71, 507–511 (1974).

    Article  ADS  CAS  Google Scholar 

  9. Darlington, A. J., and Scazzocchio, C., J. Bact., 93, 937–940 (1967).

    CAS  PubMed  Google Scholar 

  10. Scazzocchio, C., thesis, University of Cambridge (1966).

  11. Silverstone, A. E., Arditti, R. R., and Magasanik, B., Proc. natn. Acad. Sci. U.S.A., 66, 773–779 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Beckwith, J., Grodzicker, T., and Arditti, R., J. molec. Biol., 69, 155–160 (1972).

    Article  CAS  Google Scholar 

  13. Smith, T. F., and Sadler, J. R., J. molec. Biol., 59, 273–305 (1971).

    Article  CAS  Google Scholar 

  14. Maurer, R., Maniatis, T., and Ptashne, M., Nature, 249, 221–223 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Ordal, G. W., and Kaiser, A. D., J. molec. Biol., 79, 709–722 (1973).

    Article  CAS  Google Scholar 

  16. Clutterbuck, A. J., and Cove, D. J., in CRC H andbook of Microbiology, 4, (edit. by Laskin, A. I., and Lechevalier, H.), 665–676 (Chemical Rubber Co., Clevel and, 1974).

    Google Scholar 

  17. Hynes, M. J., and Pateman, J. A. J., Molec. gen. Genet., 108, 97–106 (1970).

    Article  CAS  Google Scholar 

  18. Hynes, M. J., J. Bact., 111, 717–722 (1972).

    CAS  PubMed  Google Scholar 

  19. Alderson, T., and Hartley, M. J., Mutation Res., 8, 255–264 (1969).

    Article  CAS  Google Scholar 

  20. Scazzocchio, C., Molec. gen. Genet., 125, 147–155 (1973).

    Article  CAS  Google Scholar 

  21. Englesberg, E., Sheppard, D., Squires, C., and Meronk, F., Jr, J. molec. Biol., 43, 281–298 (1969).

    Article  CAS  Google Scholar 

  22. Hofnung, M., and Schwartz, M., Molec. gen. Genet., 112, 117–132 (1971).

    Article  CAS  Google Scholar 

  23. Hynes, M. J., Biochem. biophys. Res. Commun., 54, 685–689 (1973).

    Article  CAS  Google Scholar 

  24. Alderson, T., and Scazzocchio, C., Mutation Res., 4, 567–577 (1967).

    Article  CAS  Google Scholar 

  25. McCully, K. S., and Forbes, E., Genet. Res., 6, 352–359 (1965).

    Article  CAS  Google Scholar 

  26. Cove, D. J., Biochim. biophys. Acta, 113, 51–56 (1966).

    Article  CAS  Google Scholar 

  27. Clutterbuck, A. J., J. gen. Microbiol., 70, 423–435 (1972).

    Article  CAS  Google Scholar 

  28. Arst, H. N., Jr and Page, M. M., Molec. gen. Genet., 121, 239–245 (1973).

    Article  CAS  Google Scholar 

  29. Scazzocchio, C., and Darlington, A. J., Biochim. biophys. Acta, 166, 557–568 (1968).

    Article  CAS  Google Scholar 

  30. Darlington, A. J., and Scazzocchio, C., Biochim. biophys. Acta, 166, 569–571 (1968).

    Article  CAS  Google Scholar 

  31. Layne, E., in Methods in Enzymology, 3, (edit. by Colowick, S. P., and Kaplan N. O.), 447–454 (Academic, New York, 1957).

    Book  Google Scholar 

Download references

Author information

Author notes

  1. Claudio Scazzocchio

    Present address: Department of Biology, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK

Authors and Affiliations

  1. Department of Genetics, University of Cambridge, Milton Road, Cambridge, CB4 1XH, UK

    Herbert N. Arst Jr & Claudio Scazzocchio

Authors
  1. Herbert N. Arst Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudio Scazzocchio
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arst, H., Scazzocchio, C. Initiator constitutive mutation with an ‘up-promoter’ effect in Aspergillus nidulans. Nature 254, 31–34 (1975). https://doi.org/10.1038/254031a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/254031a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing