Abstract
DR CUNNINGHAM REPLIES—Plaque morphology has been used1–5 as a simple way of distinguishing cells making different antibody specificities. Other interpretations of the meaning of plaque differences are possible, and Goldstein6 has suggested that rate of antibody secretion is decisive. As with any complex assay system, it is impossible to discount such alternative interpretations absolutely. The question is not, ‘are such artefacts conceivable?’—for evidently they are—but ‘are they likely to occur under the experimental conditions?’ Control experiments and arguments for the validity of plaque morphology as a specificity marker have been presented elsewhere7. Some of these are listed below.
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Pilarski, L. M., and Cunningham, A. J., Eur. J. Immunol., (in the press).
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CUNNINGHAM Effect of antibody emission rates on plaque morphology (reply). Nature 253, 639 (1975). https://doi.org/10.1038/253639a0
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DOI: https://doi.org/10.1038/253639a0
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