Abstract
THE proliferation of macrophages in inflammatory exudates1–3 contrasts with the failure of these cells to divide in vitro except in the presence of highly specialised conditioned media4–7. Macrophage division in vivo, however, could be explained if inflammation produced a local mitogenic factor.
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Spector, W. G., and Lykke, A. W. J., J. Path. Bact., 92, 163 (1966).
Spector, W. G., and Willoughby, D. A., J. Path. Bact., 96, 389 (1968).
Mariano, M., and Spector, W. G., J. Path. Bact., 113, 1 (1974).
Gordon, S., and Cohn, Z. A., Int. Rev. Cytol., 36, 171 (1973).
Virolainen, M., and Defendi, V., Wistar Inst. Symp. Monogr., No. 7, 67 (1967).
Mauel, J., and Defendi, V., Expl Cell Res., 65, 13 (1971).
Mauel, J., and Defendi, V., Expl Cell Res., 65, 377 (1971).
Jacoby, F., and Lee, C. G., J. Physiol., Lond., 203, 20 (1969).
Calderson, J., and Unanve, E. R., Nature, 253, 359 (1975).
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ADOLPHE, M., FONTAGNE, J., PELLETIER, M. et al. Induction of DNA synthesis in rat macrophages in vitro by inflammatory exudate. Nature 253, 637 (1975). https://doi.org/10.1038/253637a0
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DOI: https://doi.org/10.1038/253637a0
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