Abstract
MOUSE peritoneal macrophages in culture are blocked in the G0 phase of the cell cycle1 and can be stimulated to synthesise DNA and divide in vitro only by exposure to feeder layers or to medium conditioned by other cell types2–4. A similar system has been reported for mouse alveolar macrophages5. This reluctance to divide in vitro contrasts with the striking proliferation of inflammatory macrophages in vivo6,7.
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References
Gordon, S., and Cohn, Z. A., Int. Rev. Cytol., 36, 171 (1973).
Virolainen, M., and Defendi, V., Wistar Inst. Symp. Monogr., No. 7, 67 (1967).
Mauel, J., and Defendi, V., Expl. Cell Res., 65, 33 (1971).
Mauel, J., and Defendi, V., Expl. Cell Res., 65, 377 (1971).
Soderland, S. C., and Naum, V., Nature, 245, 150 (1975).
Spector, W. G., and Lykke, A. W. J., J. Path. Bact., 92, 163 (1966).
Mariano, M., and Spector, W. G., J. Path. Bact., 113, 1 (1974).
Calderson, J., and Unanue, E. R., Nature, 253, 359 (1975).
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WYNNE, K., SPECTOR, W. & WILLOUGHBY, D. Macrophage proliferation in vitro induced by exudates. Nature 253, 636–637 (1975). https://doi.org/10.1038/253636a0
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DOI: https://doi.org/10.1038/253636a0
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