Abstract
ADMINISTRATION of oestrogen to an ovariectomised or immature rat promotes a rapid increase in the content of water and univalent electrolytes in uterus and vagina1,2. Although alterations in the uptake and retention of calcium and other divalent cations by several hormone-responsive tissues have been reported following long term administration of oestrogen in vivo3,4 and during the oestrous cycle5, no information is available on the cellular exchange, if any, of calcium shortly after administration of oestrogen in sensitive targets. In view of evidence suggesting a critical role for calcium in the initiation and/or regulation of cell growth and metabolism6,7, consideration of the (potential involvement of this cation in the uterine response to oestrogen is important to analysis of steroid hormone action at the cellular level. Using endometrial cell suspensions isolated from the uteri of ovariectomised rats8, we have now shown that physiological levels of oestradial-17β influence rates of cellular calcium exchange as early as 2.5 min after in vitro addition of hormone.
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PIETRAS, R., SZEGO, C. Endometrial cell calcium and oestrogen action. Nature 253, 357–359 (1975). https://doi.org/10.1038/253357a0
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DOI: https://doi.org/10.1038/253357a0
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