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Delayed tumour appearance and absence of regression in nude mice infected with murine sarcoma virus

Nature volume 253, pages 142–144 (1975)Cite this article

Abstract

THE murine sarcoma virus (MSV) rapidly induces local tumours in mice1,2. The subsequent regression of such tumours in adult mice has been shown to be immunological in nature1,2. Young animals1,2 as well as animals immunosuppressed by X irradiation3, cortisol4, cyclophosphamide5, antilymphocyte serum6 or thymectomy2,7 have increased frequency of progressively growing tumours. The immunological nature of these phenomena was also demonstrated by the transfer of resistance to tumour growth with cells3 or serum2,5,8 from animals that had regressing tumours. The in vitro testing of lymphoid cells from mice with regressing tumours has indicated that both thymus-dependent (T)9 and non-T lymphocytes10 are generated as effector cells in this system.

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  1. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021

    OSIAS STUTMAN

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  1. OSIAS STUTMAN
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STUTMAN, O. Delayed tumour appearance and absence of regression in nude mice infected with murine sarcoma virus. Nature 253, 142–144 (1975). https://doi.org/10.1038/253142a0

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