Abstract
ACCORDING to Medawar's concept of peripheral sensitisation1,2 the induction phase of contact sensitivity may consist of a sequence of three stages. These are the formation of antigen by conjugation of the hapten with skin proteins; the recognition of this antigen by circulating lymphocytes and the activation of these cells passing by the site of antigen application; and the proliferation and differentiation of these activated lymphocytes in the draining lymph node resulting in development of memory and affector cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Medawar, P. B., Proc. R. Soc., B 149, 145–166 (1958).
Medawar, P. B., Br. med. Bull., 21, 97–99 (1965).
Macher, E., and Sommer, G., Monogr. Allergy, 8, 110–119 (Karger, Basel, 1974).
Frey, J. R., de Weck, A. L., and Geleick, H., J. invest. Derm., 42, 41–47 (1964).
Baumgarten, A., and Geczy, A. F., Immunology, 19, 205–217 (1970).
Asherson, G. L., Allison, A. C., and Zembala, M., Immunology, 22, 465–473 (1972).
McFarlin, D. E., and Balfour, B., Immunology, 25, 995–1009 (1973).
Polak, L., Geleick, H., and Frey, J. R., Monogr. Allergy, 8, 168–179 (Karger, Basel, 1974). Polak, L., and Turk, J. L., Nature, 249, 654–656 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLAK, L., MACHER, E. In vitro sensitisation to dinitrochlorobenzene in guinea pigs. Nature 252, 748–749 (1974). https://doi.org/10.1038/252748a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/252748a0
This article is cited by
-
Induction of contact photosensitivity to TCSA using photohapten-modified syngeneic spleen cells
Archives of Dermatological Research (1988)
-
Antigen formation in metal contact sensitivity
Nature (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.