Abstract
THE injection of adult mice with ultracentrifuged heterologous γ globulin induces immunological unresponsiveness to a subsequent injection of the globulin incorporated in incomplete or complete Freund's adjuvant1. It has been reported that inbred strains of mice differ in their susceptibility to the induction of unresponsiveness. Bovine γ globulin (BGG), human γ globulin (HGG) and rabbit γ globulin (RGG) easily produce tolerance in C57BL/6 and DBA/2 mice but not in BALB/c mice2,3. Passage of BGG through the circulation of BALB/c mice (but not DBA/2 mice) gives preparations which produce a high degree of tolerance in the recipient mice suggesting that strain differences in the induction of tolerance are related to the capacity of the reticuloendothelial system to process the immunogenic component in ultracentrifuged soluble BGG (sBGG). Here, we report that the administration of carrageenin, which is known to be toxic for macrophages destroys the resistance to tolerance induction in BALB/c mice. Also spleen and bone marrow cells transferred from BALB/c mice to irradiated DBA/2 mice to form chimaeras, do not show characteristic BALB/c resistance to induction of tolerance until twelve weeks after transfer.
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LUKIC, M., LESKOWITZ, S. Tolerance induction with bovine γ globulin in mouse radiation chimaeras depends on macrophages. Nature 252, 605–607 (1974). https://doi.org/10.1038/252605a0
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DOI: https://doi.org/10.1038/252605a0
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