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Protein synthesis and the release of the replicated chromosome from the cell membrane

Abstract

IN Escherichia coli, chromosome replication must be followed by a short period of protein synthesis for subsequent division of the cell1. The protein synthesised during this period has been termed ‘termination protein’1,2. We have set out to test the hypothesis2 that this post-replication protein synthesis is required to release the chromosomal DNA from its attachment to the cell membrane and that this detachment is necessary for subsequent cell division. The results of the experiments reported here provide support for this model.

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JONES, N., DONACHIE, W. Protein synthesis and the release of the replicated chromosome from the cell membrane. Nature 251, 252–254 (1974). https://doi.org/10.1038/251252a0

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