Abstract
DURING the development of mammals with X and Y chromosomes the Y chromosome brings about the differentiation of the gonad primordia into testes1. But apart from carrying the genetic determinants of maleness, little is known about its genetic constitution. In man, the gene for hairy tips to the ears shows Y linkage in at least some pedigrees2. In mice there is evidence for a Y-linked histocompatibility locus3,4, and for effects of the Y chromosome on the frequency of spermatozoa with abnormal heads5. Here we show that the size of the testes of adult mice is affected by factors on the Y chromosome.
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References
Welshons, W. J., and Russell, L. B., Proc. natn. Acad. Sci., U.S.A., 45, 560–566 (1959).
Dronamraju, K. R., Adv. Genet., 13, 225–310 (1965).
Eichwald, E. J., and Silmser, C. R., Transpln Bull., 5, 148–149 (1955).
Polácková, M., and Vojtísková, M., Folia biol., Praha, 19, 281–288 (1973).
Krzanowska, H., Genet. Res. 13, 17–24 (1969): Proc. int. Symp. Genet. Spermatozoon, 370–386, (edit. Beatty, R. A., and Gluecksohn-Waelsch, S., University of Edinburgh, 1972).
Shire, J. G. M., Excerpta Medica Int. Congr. Ser., 184, 328–332 (1969).
Shire, J. G. M., and Bartke, A., J. Endocr., 55, 163–171 (1972).
Hayward, P., Thesis, University of Cambridge, (1973).
Bartke, A., and Krzanowska, H., J. Hered., 63, 172–174 (1972).
Bartke, A., and Shire, J. G. M., J. Endocr., 55, 173–184 (1972).
Chai, C. K., Anat. Rec., 126, 269–282 (1956).
Bartke, A., J. Endocr., 60, 145–148 (1974).
Iványi, P., Gregorová, S., and Micková, M., Folia biol., Praha, 18, 81–97 (1972).
Mittwoch, U., Genetics of Sex Differentiation (Academic Press, London, 1973).
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HAYWARD, P., SHIRE, J. Y chromosome effect on adult testis size. Nature 250, 499–500 (1974). https://doi.org/10.1038/250499a0
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DOI: https://doi.org/10.1038/250499a0
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