Abstract
ASPIRIN consumption is associated with gastric mucosal erosions1,2 and upper gastrointestinal haemorrhage3–5, and has been postulated as a factor in the development of chronic peptic ulcer6,7. It has been reported to cause chronic gastric ulcer in rats8. There is, however, no real understanding of the mechanism of these injuries. Menguy et al.9 suggested that the damage to the gastric mucosa results from lack of energy (ATP) for cell function. The reported antagonism of cholera enterotoxin by aspirin in the rat intestine10 might have been mediated through the inhibition of adenyl cyclase. We have now found, however, that aspirin can stimulate the activity of this enzyme in rat gastric mucosa.
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MANGLA, J., KIM, Y. & RUBULIS, A. Adenyl cyclase stimulation by aspirin in rat gastric mucosa. Nature 250, 61–62 (1974). https://doi.org/10.1038/250061a0
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DOI: https://doi.org/10.1038/250061a0
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