Abstract
THE spin lattice relaxation time (T1) is the exponential time constant for re-equilibration of nuclear spins with their surroundings (the lattice) following resonance excitation, and is consequently related to the correlation time of the nuclei in solution. Thus, the determination of T1 values would be of interest in many biological systems. Measurement of the relative motility of different portions of a protein molecule, for example, could shed light on conformational and functional properties.
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References
Farrar, T. C., and Becker, E. D., Pulse and Fourier Transform NMR (Academic Press New York, 1971).
Benz, F. W., Roberts, G. C. K., Feeney, J., and Ison, R. R., Biochim. biophys. Acta, 278, 233 (1972).
Arata, Y., Khalifah, R., and Jardetzkey, O., Ann. N.Y. Acad. Sci., 222, 230 (1973).
Pesando, J., Fedn Proc., 31, 452 (1972).
Coates, H. B., McLauchlan, K. A., Campbell, I. D., and McColl, C. E., Biochim. Biophys. Acta, 310, 1 (1973).
Sternlicht, H., Kenyon, G. L., Packer, E. L., and Sinclair, J., J. Am. chem. Soc., 93, 199 (1971).
Allerhand, A., Doddrell, D., Glushko, V., Cochran, D. W., Wenkert, E., Lawson, P. J., and Gurd, F. R. N., J. Am. chem. Soc., 93, 544 (1971).
Glushko, V., Lawson, P. J., and Gurd, F. R. N., J. biol. Chem., 247, 3176 (1972).
Smith, I. C. P., DesLauriers, R., Saito, H., Walters, R., Garrigou-Lagrande, C., McGregor, H., and Sarantakis, D., Ann. N.Y. Acad. Sci., 222, 597 (1973).
Browne, D. T., Kenyon, G. L., Packer, E. L., Wilson, D. M., and Sternlicht, H., Biochem. biophys. Res. Commun., 50, 42 (1973).
Chaiken, I., Freedman, M. H., Lyerla, J. R., jun., and Cohen, J. S., J. biol. Chem., 248, 844 (1973).
Sachs, D. H., Schechter, A. N., and Cohen, J. S., J. biol. Chem., 246, 6576 (1971).
Cohen, J. S., Griffin, J. H., and Schechter, A. N., J. biol. Chem., 248, 4305 (1973).
Meiboom, S., Luz, Z., and Gill, D., J. chem. Phys., 27, 1411 (1957).
Glick, R. E., and Tewari, K. C., J. chem. Phys., 44, 546 (1965); Nature 211, 739 (1966).
Morgan, L. O., and Nolle, A. W., J. chem. Phys., 31, 365 (1959).
Jardetzky, O., Adv. Chem. Phys., 7, 499 (1964).
Martinez-Carrera, S., Acta Cryst., 20, 783 (1966).
Israeli, J., and Saulnier, H., Inorg. Chem. Acta., 2, 482 (1968).
Sunberg, R. G., and Martin, R. B., Chem. Res. (in the press).
Walter, W. R., Shaw, Y. L., and Li, N. C., J. Coord. Chem., 3, 77 (1973).
Wong, Y. P., J. Am. chem. Soc., 95, 3511 (1973).
Pieber, M., Kroon, P. A., Prestegard, J. H., and Chan, S. I., J. Am. chem. Soc., 95, 3408 (1973).
Gorenstein, D. G., and Wyrwicz, A., Biochem., biophys. Res. Commun., 54, 976 (1973).
Sigel, H., and McCormick, D. B., J. Am. chem. Soc., 93, 2041 (1971).
Patel, D. J., Woodward, C. K., and Bovey, F. A., Proc. natn. Acad. Sci. U.S.A., 69, 599 (1972).
McDonald, C. C., and Phillips, W. D., Biochemistry, 12, 3170 (1973).
Bradbury, J. H., Chapman, B. E., and King, N. L. R., Int. J. protein Res., 3, 351 (1971).
Richards, F. M., and Wyckoff, M. W., in The Enzymes (edit. by Boyer, P.), 4, 647 (Academic Press, New York, 1971).
Ihnat, M., Biochemistry, 11, 3483 (1972).
Kotowycz, G., and Suzuki, O., Biochemistry, 12, 5325 (1973).
Putter, J., Barretto, A., Markley, J. L., and Jardetzky, O., Proc. natn. Acad. Sci. U.S.A., 64, 1396 (1969).
Cuatrecasas, P., Fuchs, S., and Anfinsen, C. B., J. biol. Chem., 242, 3063 (1967).
Meadows, D. H., Jardetzky, O., Epand, R. M., Ruterjans, H. H., and Scheraga, H. A., Proc. natn. Acad. Sci. U.S.A., 60, 766 (1968).
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WASYLISHEN, R., COHEN, J. Spin-lattice relaxation times of imidazole protons and their relevance to NMR studies of proteins. Nature 249, 847–850 (1974). https://doi.org/10.1038/249847a0
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DOI: https://doi.org/10.1038/249847a0
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