Abstract
CHICKENS of the Obese strain (OS) spontaneously develop severe autoimmune thyroiditis during the first weeks of life, with clinical signs of hypothyroidism1,2. Serological tests reveal both circulating and bound thyroglobulin autoantibodies3. The lymphoid infiltration of the thyroid gland is characterised by a predominance of plasma cells and the formation of a large number of germinal centres1. In view of the histological and serological features, the spontaneous autoimmune thyroiditis of OS chickens can be considered as an appropriate animal model for human Hashimoto thyroiditis2.
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References
Cole, R. K., Kite, J. H., jun., and Witebsky, E., Science, 160, 1357 (1968).
Wick, G., Sundick, R. S., and Albini, B., Clin. Immun. Immunopath., (in the press).
Wick, G., Witebsky, E., Kite, J. H., jun., and Beutner, E. H., Clin. exp. Immun., 7, 173 (1970).
Witebsky, E., Kite, J. H., jun., Wick, G., and Cole, R. K., J. Immun., 193, 708 (1969).
Sundick, R. S., and Wick, G., Gen. comp. Endocr. (in the press).
Wick, G., Clin. exp. Immun., 7, 187 (1970).
Albini, B., and Wick, G., Immunology, 21, 957 (1971).
Wick, G., Kite, J. H., jun., Cole, R. K., and Witebsky, E., J. Immun., 104, 45 (1970).
Albini, B., and Wick, G., Immunology, 24, 545 (1973).
Wick, G., and Steiner, R., J. Immun., 109, 471 (1972).
Wick, G., and Albini, B., in Immunopathology, 7th Int. Symp., (edit. by Miescher, P. A.) (in the press).
Wick, G., Albini, B., and Milgrom, F., Clin. exp. Immun., 15, 237 (1973).
Albini, B., and Wick, G., Int. Arch. Allergy, 44, 804 (1973).
Möller, G., J. exp. Med., 114, 415 (1961).
Albini, B., and Wick, G., J. Immun., 112, 444 (1974).
Stobo, J. D., Talal, N., and Paul, W. E., J. Immun., 109, 701 (1972).
Waksman, B. H., Raff, M. C., and East, J., Clin. exp. Immun., 11, 1 (1972).
Wick, G., and Witebsky, E., Int. Arch. Allergy, 40, 603 (1971).
Chused, T. M., Hardin, J. A., Frank, M. M., and Green, I., J. Immun., 112, 641 (1974).
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ALBINI, B., WICK, G. Proportional increase of bursa-derived cells in chickens of the Obese strain. Nature 249, 653–654 (1974). https://doi.org/10.1038/249653a0
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DOI: https://doi.org/10.1038/249653a0
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