Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Molecular basis of control of mitotic cell division in eukaryotes

Abstract

MITOTIC division in Physarum polycephalum is preceded by a marked increase in the phosphate content of very lysine-rich histone (Pp. F1) (ref. 1) due to phosphorylation of serine residues probably at specific points in the amino acid sequence2,3. The phosphate content of F1 histone has been measured by a number of groups under a variety of conditions in an attempt to understand the role of F1 phosphorylation and three facts have been established.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bradbury, E. M., Inglis, R.J., Matthews, H. R., and Sarner, N., Eur. J. Biochem., 33, 131 (1973).

    Article  CAS  Google Scholar 

  2. Langan, T.A., Ann. N.Y. Acad. Sci., 185, 166 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Dixon, G. H., Louie, A. J., McLeod, A. R., and Sing, M. T., Trans. Biochem. Soc. (in the press).

  4. Panyim, S., and Chalkley, R., Biochemistry, 8, 3972 (1969).

    Article  CAS  Google Scholar 

  5. Oliver, D., Balhorn, R., Granner, D., and Chalkley, R., Biochemistry, 11, 3921 (1972).

    Article  CAS  Google Scholar 

  6. Balhorn, R., Chalkley, R., and Granner, D., Biochemistry, 11, 1094 (1972).

    Article  CAS  Google Scholar 

  7. Balhorn, R., Riecke, O., and Chalkley, R., Biochemistry, 10, 3952 (1971).

    Article  CAS  Google Scholar 

  8. Balhorn, R., Balhorn, M., Morris, H. P., and Chalkley, R., Cancer Res., 32, 1775 (1972).

    CAS  Google Scholar 

  9. Stevely, W. S., and Stocken, L. A., Biochem. J., 110, 187 (1968).

    Article  CAS  Google Scholar 

  10. Balhorn, R., Bordwell, J., Sellers, L., Granner, D., and Chalkley, R., Biochem. biophys. Res. Commun., 46, 1326 (1972).

    Article  CAS  Google Scholar 

  11. Gurley, L. R., Walters, R. A., and Tobey, R. A., Biochem. biophys. Res. Commun., 50, 744 (1973).

    Article  CAS  Google Scholar 

  12. Balhorn, R., Tanphaichitr, N., Chalkley, R., and Granner, D.K., Biochemistry, 12, 5146 (1973).

    Article  CAS  Google Scholar 

  13. Marks, D.B., Paik, W. K., and Borun, T. W., J. biol. Chem., 248, 5600 (1973).

    Google Scholar 

  14. Gurley, L. R., Walters, R. A., and Tobey, R. A., J. Cell. Biol. (in the press).

  15. Lake, R. S., and Salzman, N. P., Biochemistry, 11, 4817 (1972).

    Article  CAS  Google Scholar 

  16. Lake, R. S., Nature new Biol., 242, 145 (1973).

    Article  CAS  Google Scholar 

  17. Bradbury, E. M., Inglis, R. J., and Matthews, H. R., Nature, 247, 257 (1974).

    Article  ADS  CAS  Google Scholar 

  18. Lake, R. S., J.Cell Biol., 58, 317 (1973).

    Article  CAS  Google Scholar 

  19. Oppenheim, A., and Katzir, N., Expl Cell Res., 68, 224 (1971).

    Article  CAS  Google Scholar 

  20. Inglis, R. J., thesis, Univ. London (1974).

  21. Bradbury, E. M., Carpenter, B. G., and Rattle, H. W. E., Nature, 241, 123 (1973).

    Article  ADS  CAS  Google Scholar 

  22. Chin, B., Friedrich, P. D., and Bernstein, I. A., J. gen. Microbiol., 71, 93 (1972).

    Article  CAS  Google Scholar 

  23. Sachsenmaier, W., Remy, U., and Plattner-Schoebel, R., Expl Cell Res., 73, 41 (1972).

    Article  CAS  Google Scholar 

  24. Brewer, E. N., and Rusch, H. P., Expl Cell Res., 49, 79 (1968).

    Article  CAS  Google Scholar 

  25. Mohberg, J., and Rusch, H. P., Archs Biochem. Biophys., 138, 418 (1970).

    Article  CAS  Google Scholar 

  26. Rusch, H. P., Adv. Cell Biol., 1, 297 (1971).

    Google Scholar 

  27. Guttes, E., and Guttes, S., in Methods in Cell Physiology (edit. by Prescott, D. M.) 43 (Academic Press, New York, 1964).

    Google Scholar 

  28. Daniel, J. W., and Baldwin, H. H., in Methods in Cell Physiology. (edit. by Prescott, D. M.) 9 (Academic Press, New York, 1964).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRADBURY, E., INGLIS, R., MATTHEWS, H. et al. Molecular basis of control of mitotic cell division in eukaryotes. Nature 249, 553–556 (1974). https://doi.org/10.1038/249553a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/249553a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing