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UGA and non-triplet suppressor reading of the genetic code

Nature volume 249, pages 527–530 (1974)Cite this article

Abstract

Mutants in a tRNA methylase gene, supK, of Salmonella typhimurium give suppression of UGA and certain frameshift mutants. In addition suppressors which do not suppress UGA, but which suppress frameshift mutants of opposite (effective) signs are described.

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References

  1. Brenner, S., Barnett, L., Crick, F. H. C., and Orgel, A., J. molec. Biol., 3, 121–124 (1961).

    Article  CAS  Google Scholar 

  2. Crick, F. H. C., Barnett, L., Brenner, S., and Watts-Tobin, R. J., Nature, 192, 1227–1232 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Terzaghi, E., Okada, Y., Streisinger, G., Emrich, J. Inouye, M., and Tsugita, A., Proc. natn. Acad. Sci. U.S.A., 56, 500–507 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Barnett, L., Brenner, S., Crick, F. H. C., Shulman, R. G., and Watts-Tobin, R. J., Phil. Trans. R. Soc. Lond., B 252, 487–560 (1967).

    Google Scholar 

  5. Laux, B., Dennis, D., and White, H. B., Biochem. biophys. Res. Commun., 54, 894–898 (1973).

    Article  CAS  PubMed  Google Scholar 

  6. Ames, B. N., Durston, W. E., Yamasaki, E., and Lee, F. D., Proc. natn. Acad. Sci. U.S.A., 70, 2281–2285 (1973).

    Article  ADS  CAS  Google Scholar 

  7. Riyasaty, S., and Atkins, J. F., J. molec. Biol., 34, 541–557 (1968).

    Article  CAS  PubMed  Google Scholar 

  8. Yourno, J., and Heath, S., J. Bact., 100, 460–468 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Riddle, D. L., and Roth, J. R., J. molec. Biol., 54, 131–144 (1970).

    Article  CAS  PubMed  Google Scholar 

  10. Smith, J. D., A. Rev. Genet., 6, 235–256 (1973).

    Article  Google Scholar 

  11. Hartman, P. E., and Roth, J. R., Adv. Genet., 17, 1–105 (1973).

    Article  CAS  PubMed  Google Scholar 

  12. Yourno, J., and Kohno, T., Science, 175, 650–652 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Yourno, J., Nature new Biol., 239, 219–221 (1972).

    Article  CAS  PubMed  Google Scholar 

  14. Yourno, J., and Tanemura, S., Nature, 225, 422–426 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Riddle, D. L., and Roth, J. R., J. molec. Biol., 66, 495–506 (1972).

    Article  CAS  PubMed  Google Scholar 

  16. Riddle, D. L., and Carbon, J., Nature new Biol., 242, 230–234 (1973).

    Article  CAS  PubMed  Google Scholar 

  17. Atkins, J. F., Elseviers, D., and Gorini, L., Proc. natn. Acad. Sci. U.S.A., 69, 1192–1195 (1972).

    Article  ADS  CAS  Google Scholar 

  18. Reeves, R. H., and Roth, J. R., J. molec. Biol., 56, 523–533 (1971).

    Article  CAS  PubMed  Google Scholar 

  19. Oeschger, N. S., and Hartman, P. E., J. Bact., 101, 490–504 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Yourno, J., J. molec. Biol., 48, 437–442 (1970).

    Article  CAS  PubMed  Google Scholar 

  21. Whitfield, H. J., jun., Martin, R. G., and Ames, B. N., J. molec. Biol., 21, 335–355 (1966).

    Article  CAS  PubMed  Google Scholar 

  22. Riddle, D. L., and Roth, J. R., J. molec. Biol., 66, 483–493 (1972).

    Article  CAS  PubMed  Google Scholar 

  23. Smith, H. O., and Levine, M., Virology, 31, 207–216 (1967).

    Article  CAS  PubMed  Google Scholar 

  24. Apirion, D., Phillips, S. L., and Schlessinger, D., Cold Spring Harbor Symp. quant. Biol., 34, 117–128 (1969).

    Article  CAS  PubMed  Google Scholar 

  25. Ganoza, M. C., Vandermeer, J., Debreceni, N., and Phillips, S. L., Proc. natn. Acad. Sci. U.S.A., 70, 31–35 (1973).

    Article  ADS  CAS  Google Scholar 

  26. Apte, B. N., and Zipser, D., Proc. natn. Acad. Sci. U.S.A., 70, 2969–2973 (1973).

    Article  ADS  CAS  Google Scholar 

  27. Miller, C. G., and Roth, J. R., J. molec. Biol., 59, 63–75 (1971).

    Article  CAS  PubMed  Google Scholar 

  28. Greeb, J., Atkins, J. F., and Loper, J.C., J. Bact., 106, 421–431 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Nishimura, S., Prog. Nucleic Acid Res. molec. Biol., 12, 49–85 (1972).

    Article  CAS  Google Scholar 

  30. Furuichi, Y., and Ukita, T., Biochem. biophys. Res. Commun., 41, 797–803 (1970).

    Article  CAS  PubMed  Google Scholar 

  31. Eisinger, J., and Spahr, P.-F., J. molec. Biol., 73, 131–137 (1973).

    Article  CAS  PubMed  Google Scholar 

  32. Uhlenbeck, O. C., J. molec. Biol., 65, 25–41 (1972).

    Article  CAS  PubMed  Google Scholar 

  33. Hirsh, D., J. molec. Biol., 58, 439–458 (1971).

    Article  CAS  PubMed  Google Scholar 

  34. Model, P., Webster, R. E., and Zinder, N. D., J. molec. Biol., 43, 177–190 (1969).

    Article  CAS  PubMed  Google Scholar 

  35. Roth, J. R., J. Bact., 102, 467–475 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. J. F. Atkins

    Present address: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724

Authors and Affiliations

  1. Department of Genetics, Trinity College, Dublin, 2, Ireland

    J. F. Atkins & S. Ryce

Authors
  1. J. F. Atkins
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  2. S. Ryce
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Atkins, J., Ryce, S. UGA and non-triplet suppressor reading of the genetic code. Nature 249, 527–530 (1974). https://doi.org/10.1038/249527a0

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  • DOI: https://doi.org/10.1038/249527a0

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