Abstract
INTEREST in the regulation of the immune response to nucleic acids stems largely from the spontaneous occurrence of anti-nucleic acid antibodies in the sera of patients with systemic lupus erythematosus1–4. Genetic factors seem to play a role in this disease, which is associated with certain human transplantation antigens5. Spontaneous production of antibodies to different forms of nucleic acids has been observed in some mouse strains, and is suggested to be correlated with autoimmune diseases1–4,6–8. It is of interest to find out whether the response potential of different mouse strains to nucleic acids, on active immunisation, is related to the spontaneous occurrence of antibodies and/or to autoimmune-like diseases.
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MOZES, E., FUCHS, S. Linkage between immune response potential to DNA and X chromosome. Nature 249, 167–168 (1974). https://doi.org/10.1038/249167a0
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DOI: https://doi.org/10.1038/249167a0
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