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The induction of tumour immunity in mice using glutaraldehyde-treated tumour cells

Nature volume 248, pages 690–691 (1974)Cite this article

Abstract

INDUCING immunity to tumours presents problems similar to those of inducing immunity to infectious microorganisms—the presentation of the agent in an antigenic but non-infectious form. Two approaches have been used to render syngeneic tumour cells non-infectious, lethal irradiation1 and treatment with chemically reactive groups such as iodo-acetamide2,3. These treatments leave the cell metabolising but incapable of division.

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References

  1. Alexander, P., Prog. exp. Tumor Res., 10, 23 (1968).

    Google Scholar 

  2. Apfel, C. A., Arnonson, B. G., and Peters, J. H., Nature, 209, 694 (1966).

    Article  ADS  Google Scholar 

  3. Prager, M. D., Derr, I., Swann, A., and Cotropia, J., Cancer Res. 31, 1488 (1971).

    CAS  PubMed  Google Scholar 

  4. Richards, F. M., and Knowles, J. R., J. molec. Biol., 37, 231 (1968).

    Article  CAS  Google Scholar 

  5. Old, J. L., and Boyse, E. A., Fedn. Proc., 24, 1009 (1965).

    CAS  Google Scholar 

  6. Parish, C. R. C., J. exp. Med., 134, 21 (1971).

    Article  CAS  Google Scholar 

  7. Parish, C. R., and Liew, F. Y., J. exp. Med., 135, 298 (1972).

    Article  CAS  Google Scholar 

  8. Lippman, M. M., Venditti, J. M., Kline, I., and Elam, D. L., Cancer Res., 33, 678 (1973).

    Google Scholar 

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Authors and Affiliations

  1. Division of Surgical Sciences, Clinical Research Centre, Watford Road, Harrow

    C. J. SANDERSON & P. FROST

Authors
  1. C. J. SANDERSON
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  2. P. FROST
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SANDERSON, C., FROST, P. The induction of tumour immunity in mice using glutaraldehyde-treated tumour cells. Nature 248, 690–691 (1974). https://doi.org/10.1038/248690a0

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