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Precursor 16S RNA in Active 30S Ribosomes

Abstract

BIOGENESIS of bacterial ribosomes proceeds through the formation of precursor particles1–4, consisting of an incomplete set of ribosomal protein5 and of RNA molecules that are longer and less methylated than mature RNA4,6,7. RNA maturation is commonly considered to be a part of the ribosome maturation process. Here we report that newly formed 30S ribosomes can enter polyribosomes while they still contain precursor RNA. Maturation of ribosomal RNA might be completed not before, but after, ribosomes have interacted with messenger RNA.

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References

  1. McCarty, B. J., Britten, R. J., and Roberts, R. P., Biophys. J., 2, 57 (1962).

    Article  Google Scholar 

  2. Mangiarotti, G., Apirion, D., Schlessinger, D., and Silengo, L., Biochemistry, 7, 456 (1968).

    Article  CAS  Google Scholar 

  3. Osawa, S., Otaka, E., Itoh, T., and Fukui, T., J. molec. Biol., 40, 321 (1969).

    Article  CAS  Google Scholar 

  4. Hayes, F., and Hayes, D. H., Biochimie, 53, 369 (1969).

    Article  Google Scholar 

  5. Nierhaus, R. H., Bondasch, K., and Homann, H. E., J. molec. Biol., 74, 587 (1973).

    Article  CAS  Google Scholar 

  6. Adesnik, M., and Levinthal, C., J. molec. Biol., 46, 281 (1969).

    Article  CAS  Google Scholar 

  7. Dahlberg, A. E., and Peacock, A. C., J. molec. Biol., 55, 61 (1971).

    Article  CAS  Google Scholar 

  8. Mangiarotti, G., Turco, E., and Silengo, L., Abstr. Commun. Meeting Fed. Eur. biochem. Soc., 8 (1972).

  9. Bolle, E., Epstein, R. H., Salser, W., and Geiduschek, E. P., J. molec. Biol., 31, 325 (1968).

    Article  CAS  Google Scholar 

  10. Mangiarotti, G., and Turco, E., Eur. J. Biochem., 38, 507 (1973).

    Article  CAS  Google Scholar 

  11. Lindahl, L., Nature new Biol., 243, 170 (1973).

    Article  CAS  Google Scholar 

  12. Green, K. H., and Hall, B. D., Biophys. J., 1, 157 (1961).

    Article  Google Scholar 

  13. Kurland, C. G., A. Rev. Biochem., 41, 377 (1972).

    Article  CAS  Google Scholar 

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MANGIAROTTI, G., TURCO, E., PONZETTO, A. et al. Precursor 16S RNA in Active 30S Ribosomes. Nature 247, 147–148 (1974). https://doi.org/10.1038/247147a0

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  • DOI: https://doi.org/10.1038/247147a0

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