Abstract
IT is now widely accepted that most, if not all, glucocorticoid responses in target tissue are mediated by specific steroid receptor molecules in the cytoplasm1,2. Following association between steroid and receptor, there is transport of the steroid to the nucleus where subsequent interaction with the genome presumably alters transcriptional processes3. This scheme does not yet satisfactorily explain the widely differing responses of various tissues to glucocorticoids. Specificity of the kind of response observed could lie in differences in the receptor molecule itself and/or in the ability of a common receptor molecule to interact only with certain ‘exposed’ parts of the nuclear material in a given cell. Some evidence has favoured the latter interpretation4, but there has not yet been support for the former contention. In this report, we present evidence that at least some degree of specificity of response may be mediated by subtle differences in the cytoplasmic corticosteroid-binding proteins between tissues with differing kinds of responses to glucocorticoids. Our data further suggest that there are intranuclear binding sites for cytoplasmic glucocorticoid receptors which are of high affinity and saturability and which can distinguish between glucocorticoid receptors of differing origin.
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LIPPMAN, M., THOMPSON, E. Differences between Cytoplasmic Glucocorticoid-binding Proteins shown by Heterogeneity of Nuclear Acceptor Sites. Nature 246, 352–355 (1973). https://doi.org/10.1038/246352a0
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DOI: https://doi.org/10.1038/246352a0
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