Abstract
MICE homozygous for the mutation nude (nu/nu) are hairless1 and deficient in thymus2–4 and thymus-derived (T)5,6 lymphocytes. They are generally referred to as being athymic and are widely used in immunology as a source of B lymphocytes uncontaminated with T cells, although there is evidence that the thymus is present, but is small and dysplastic3,4. Indirect evidence has suggested that at least some nude mice have small numbers of T cells7–9, but this has been controversial. I report here the direct demonstration by immunofluorescence of a small population of θ-bearing cells in lymph nodes and spleens of nude mice using fluorescein-conjugated anti-θ antibody.
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References
Flanagan, S. P., Genet. Res., 8, 295 (1966).
Pantelouris, E. M., Nature, 217, 370 (1968).
Pantelouris, E. M., and Hair, J., J. Embryol. exp. Morphol., 24, 615 (1970).
Wortis, H., Nehlsen, S., and Owen, J., J. exp. Med., 134, 681 (1971).
de Sousa, M. A. B., Parrott, D. M. V., and Pantelouris, E. M., Clin. exp. Immun., 4, 637 (1969).
Raff, M. C., and Wortis, H. H., Immunology, 18, 931 (1970).
Raff, M. C., Transplantn. Rev., 6, 52 (1971).
Watson, J., Epstein, R., Nakoinz, I., and Ralph, P., J. Immun., 110, 43.
Andersson, L. C., Nordling, S., and Häyry, P., Cell. Immun. (in the press).
Raff, M., Sternberg, M., and Taylor, R., Nature, 225, 553 (1970).
Reif, A. E., and Allen, J. M. V., J. exp. Med., 120, 413 (1964).
Boyle, W., Transplantation, 6, 761 (1968).
Ashman, R. F., and Raff, M. C., J. exp. Med., 137, 69 (1973).
Scheid, M., Boyse, E. A., Carswell, E. A., and Old, L. J., J. exp. Med., 135, 938 (1972).
Schlesinger, M., and Yron, I., J. Immun., 104, 798 (1970).
Aoki, T., Hämmerling, U., de Harven, E., Boyse, E. A., and Old, L. J., J. exp. Med., 130, 979 (1969).
Wortis, H. H., Clin. exp. Immun., 8, 305 (1971).
Pantelouris, E. M., Immunology, 20, 247 (1971).
Billington, W. D., Kirby, D. R. S., Owen, J. J. T., Ritter, M. A., Burtonshaw, M. D., Evans, E. P., Ford, C. E., Gauld, I. K., and McLaren, A., Nature, 224, 704 (1969).
Di George, A. M., in Birth Defects—Immunologic Deficiency Diseases in Man, 4, No. 1 (National Foundation, 1968).
McLaren, A., and Michie, D., J. exp. Med., 141, 47 (1959).
Komuro, K., and Boyse, E. A., Lancet, i, 740 (1973).
Vassalli et al., J. exp. Med., 136, 984 (1972).
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RAFF, M. θ-bearing Lymphocytes in Nude Mice. Nature 246, 350–351 (1973). https://doi.org/10.1038/246350a0
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DOI: https://doi.org/10.1038/246350a0
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